The adoption of orthobiologics as a new therapy for the treatment of several musculoskeletal conditions has skyrocketed in the last decade. Although there are a number of treatment options available for these issues these days, the use of autologous blood-derived products like Bone Marrow Aspirate Concentrate (BMAC) and Platelet Rich Plasma (PRP) is on the rise. The usefulness of PRP in the therapy of cartilage, bone, and muscle tissues is well established. When compared to PRP, BMAC has achieved promising outcomes for the same reasons, although its application in clinical investigations is still in its early stages. Both products have the ability to start healing processes, but they do so in distinct ways.
Let’s figure out the answers to some of the queries you could have concerning PRP and BMAC:
How do stem cells in Platelet Rich Plasma (PRP) and Bone Marrow Aspirate Concentrate (BMAC) help with healing?
When you are injured, your body enters a healing process that includes tissue regeneration. This mending process necessitates a variety of biological materials, including growth factors and cells. Growth factors are small signalling proteins that help the body start and regulate the healing process. By giving these growth factors or cells to the damaged location, physicians may be able to minimise or change inflammation, improve or hasten healing, and allow pain relief or rapid recovery.
Is there an upper age limit for Bone Marrow Aspirate Concentrate (BMAC) regeneration therapy?
Patients under the age of 60 who receive BMAC therapy can rebuild tissue and use their own “pluripotent” stem cells. Since the number of stem cells produced by the body begins to decline mostly around the age of 40, the body’s ability to repair tissues from autologous (own) stem cells reduces as it matures. Due to a depletion of stem cells in the bone marrow, autologous BMAC frequently fails to recover after the age of 60. Between the ages of 70 and 80, there are virtually no stem cells in the bone marrow. Because autologous stem cells are being depleted, patients over the age of 60 benefits from a combination of a healing activator, such as PRP, and allograft tissues acquired from some other source for regeneration.
Are stem cells derived from Platelet Rich Plasma (PRP) and Bone Marrow Aspirate Concentrate (BMAC) regarded as regenerative therapies?
No. PRP is not a regenerative therapy because it employs growth factors to accelerate the body’s ability to heal naturally.
BMAC, on the other hand, is classified as a regenerative therapy due to its ability to greatly increase repair and stimulate tissue regeneration. The “undifferentiated” stem cells collected from the patient and used in the BMAC treatment are “pluripotent,” which means they can replicate (or regenerate) various different types of tissues. BMAC stem cells are “autologous” tissue since they are derived from a patient’s iliac pelvic bone.
You’re probably wondering which therapy might be best for you. It’s reasonable that determining which of these two groundbreaking approaches is best for you is difficult to pin down in a blog post! As you may be aware, regenerative treatments really aren’t one-size-fits-all; every individual has a distinctive set of features that must be evaluated, analyzed, and integrated by a skilled physician in determining the most effective course of therapy. If you believe a procedure such as PRP or BMAC therapy could assist your bone-related difficulties, the first step is to schedule an appointment with a certified and trained regenerative medicine expert.