Platelet-rich plasma (PRP) is a regenerative medicine strategy that is starting to gain traction in the clinic. Platelet-Rich Plasma (PRP) is a concentrated platelet concentration extracted from blood. Growth factors are a key component of the bioactive proteins in the sample since they promote tissue revitalization and have been shown to accelerate the healing process.
Wound healing is a complex and fluid process. When a wound starts to heal, the process typically ends with tissue repair. Nonetheless, several variables such as comorbidity or infection might impact the recovery of an acute or chronic wound.
PRP for wound healing is a progressive treatment solution because chronic and acute wounds are characterised by a protracted inflammatory phase that impedes wound healing. Platelet-rich plasma has been utilised to stimulate wound healing because it contains
- Factors that promote growth
- A fibrin scaffold -derived from the blood of the patient
The molecular and cellular triggering of typical wound-healing processes, similar to that seen with platelet activation, is said to be the mechanism of action for platelet-rich plasma. PRP is a safe therapeutic option that has no negative side effects, such as an increased risk of infection or inflammation. When it comes to oncogenic potential, no evidence indicates a possible temporal triggering when the plausible coincidences between cancer and the stimulatory pathways used by growth factors are examined.
In conditions and circumstances involving bone loss, such as periodontitis, fractures, malignancies, and skeletal deformities, restoring lost bone is of paramount importance. Autogenous bone is a solution to this, although it has a variety of drawbacks, including
- Morbidity at the donor site
- Having difficulty obtaining the bone
- Healing time is lengthy
- Disease transmission risk
- Immune reaction to a foreign body
Because of the high amounts of autologous growth factors, platelet-rich plasma treatment has been shown to stimulate osteoblast (cells that make new bone) proliferation and enhance bone healing in vitro. Aside from growth factors, it moreover contains cytokines, enzymes, proteins, and fibrinolytic and anti-fibrinolytic proteins, all of which are produced when platelets are stimulated mechanically or chemically.
Growth factors such as platelet-derived growth factor (PDGF), Transforming growth factor (TGF), and Insulin-like growth factor (IGF) are linked to bone tissue regeneration and development because they are made up of proteins that are found in cells during wound healing and have thus been outlined to imitate bone regeneration environments. Availability, simplicity of isolation, excellent reliability, and storage features are all advantages of using PRP in bone regeneration. It also eliminates the possibility of transmission of disease and immunological rejection.